A clinical comparison of nano-crystalline hydroxyapatite (Ostim) and autogenous bone graft in the treatment of periodontal intrabony defects.

OBJECTIVES The aim of the present study was to evaluate the efficacy of autogenous bone graft (ABG) and nano-crystalline hydroxyapatite (Ostim) in the management of human intrabony periodontal defects. STUDY DESIGN Twenty-four similar two and three wall intrabony periodontal defects with ≥5 mm probing depths and ≥3 mm depths of intrabony component in 12 healthy patients were selected. One defect in each subject was treated with ABG (ABG group) and the contralateral one with ABG and Ostim (Ostim group). Plaque index (GI), gingival index (PI), clinical probing depth (CPD), clinical attachment level (CAL), gingival margin level, bone fill, crestal resorption and defect resolution were measured at baseline and during reentry surgery after 6 months. Wilcoxon signed-rank test and Mann-Whitney U test were used to analyze the data. RESULTS Groups showed statistically significant improvements in soft and hard tissue parameters after 6 months except in gingival margin level and crestal level. However, the between-group differences after 6 months were not statistically significant with regard to soft and hard tissue measurements. CONCLUSION Within the limits of this study, both treatments resulted in marked clinical improvement, and Ostim treatment seemed to be effective in the treatment of two & three-wall intrabony defects as well as autogenous bone graft.